R6H4 Pep-LNP

Cat. No.: TDLD-0825-LD85

R6H4 Pep-LNP

R6H4 Pep-LNP is a state-of-the-art peptide-functionalized lipid nanoparticle (LNP), designed for efficient targeted delivery of therapeutic cargoes such as siRNA, mRNA, DNA, small molecule drugs, and RNA-guided gene editing systems, particularly in acidic microenvironments like those found in tumors. Engineered with the R6H4 peptide, a pH-responsive cell-penetrating peptide composed of 6 arginine and 4 histidine residues, this LNP exhibits enhanced cellular uptake and endosomal escape within acidic conditions, enabling selective delivery of its cargo into tumor cells. Our LNP is prepared using DSPE-PEG-R6H4 and a variety of optional lipid formulations including DLin-MC3-DMA, LP-01, ALC-0315, SM102, and others. These formulations are carefully selected to ensure the LNP has uniform particle size, high encapsulation efficiency, stability, and targeted delivery. Applications of R6H4 Pep-LNP include research in targeted cancer therapy, pH-dependent drug release systems, enhancing nucleic acid delivery efficiency in tumors, and studying intracellular trafficking in acidic cellular compartments. Please note that this product is intended for research purposes only.