RVG29 Pep-LNP
Cat. No.: TDLD-0825-LD72
RVG29 Pep-LNP
RVG29 Pep-LNP is a state-of-the-art peptide-functionalized lipid nanoparticle (LNP), designed for efficient brain-targeted delivery of therapeutic cargoes such as siRNA, mRNA, DNA, small molecule drugs, and RNA-guided gene editing systems. Engineered with the RVG29 peptide, this LNP demonstrates exceptional targeting capabilities by selectively binding to nicotinic acetylcholine receptors (nAChRs) on neural cells, enabling it to traverse the blood-brain barrier (BBB) with high efficacy. Our LNP is prepared using Targeting Module and a variety of optional lipid formulations including DLin-MC3-DMA, LP-01, ALC-0315, SM102, and others. These formulations are carefully selected to ensure the LNP has uniform particle size, high encapsulation efficiency, stability, and targeted delivery. Applications of RVG29 Pep-LNP span a wide range of neuroscience research, including gene therapy for neurodegenerative diseases like Alzheimer's and Parkinson's, mRNA-based therapies for CNS disorders, and gene editing in brain cells. Please note that this product is intended for research purposes only.
| Payload Type | mRNA |
| Payload | Empty; EGFP mRNA; Firefly Luciferase mRNA; mCherry mRNA; GFP mRNA; OVA mRNA; EPO mRNA; Renilla Luciferase mRNA; Gaussia Luciferase mRNA; Beta-galactosidase mRNA; Cre mRNA; mOrange mRNA; tdTomato mRNA; EYFP mRNA; Others |
| Capping | Cap 1 |
| Modification | Unmodified; N1-methyl-pseudouridine; 5-methoxyuridine; Other |
| Module Type | Peptide |
| Targeting Module | RVG29 Peptide |
| Target | Brain |
| Lipid Formulation | DLin-MC3-DMA; LP-01; ALC-0315; SM102; Other |
| Dye | Unlabeled; DiR; DiD; DiO; DiI; Other |
| Application | Targeted Delivery; Gene Therapy |
| Format | Liquid |
| Concentration | 0.1 mg/mL; 0.2 mg/mL; Other (Please Specify) |
| Size | 65-120 nm |
| PDI | < 0.2 |
| Zeta | ± 20.0 mV |
| Encapsulate Efficiency | >90% |
| Shipping | Dry Ice |
| Storage | Store at -80°C |
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