VIP Pep-LNP

Cat. No.: TDLD-0825-LD90

VIP Pep-LNP

VIP Pep-LNP is a state-of-the-art peptide-functionalized lipid nanoparticle (LNP), designed for efficient targeted delivery of therapeutic cargoes such as siRNA, mRNA, DNA, small molecule drugs, and RNA-guided gene editing systems, particularly to the tumor microenvironment. Engineered with the VIP peptide, a 26-amino acid peptide known for its multiple biological activities and ability to specifically bind G protein-coupled receptors (VPAC1 and VPAC2), this LNP allows for selective targeting of cells or tissues where VIP receptor expression is elevated, such as in certain inflammatory conditions, neurodegenerative diseases, and specific cancers, enabling modulation of associated physiological functions like vasodilation, immune regulation, and neuroprotection. Our LNP is prepared using DSPE-PEG-VIP and a variety of optional lipid formulations including DLin-MC3-DMA, LP-01, ALC-0315, SM102, and others. These formulations are carefully selected to ensure the LNP has uniform particle size, high encapsulation efficiency, stability, and targeted delivery. Applications of VIP Pep-LNP include research in targeted therapy for VIP receptor-expressing cancers, modulation of inflammatory responses, development of neuroprotective strategies, and studying the role of VIP signaling in various disease models. Please note that this product is intended for research purposes only.