Animal Model Development Services for TIL Therapy Development

TILs are a critical component of the immune response against cancer, representing a promising avenue for immunotherapy. The study of TILs is essential for understanding how the immune system interacts with tumors and developing effective cancer treatments. To facilitate this research, Creative Biolabs offers a range of advanced animal models specifically designed for in vivo testing of TILs, including immunocompetent mouse models, humanized mice models, and patient-derived xenograft (PDX) models.

• Syngeneic Tumor Models: These models involve transplanting mouse cancer cell lines into genetically identical mice, allowing researchers to study immune responses in a consistent genetic background. This setup is beneficial for assessing the activation and proliferation of TILs in response to various immunotherapeutic agents.
• Genetically Engineered Mouse Models (GEMMs): GEMMs are designed to mimic specific genetic mutations found in human cancers, enabling the study of TILs in a context that closely resembles human tumor biology. These models allow researchers to investigate the mechanisms of tumorigenesis and the role of TILs in tumor progression.
• Murine Tumor Homograft Models: By transplanting tumors derived from GEMMs or carcinogen-induced tumors into mice, these models provide a patient-relevant environment for studying TIL interactions with the tumor microenvironment. This is essential for evaluating the efficacy of therapies aimed at enhancing TIL activity.

• CD34+ Humanized Mice: These models are implanted with human hematopoietic stem cells, resulting in a functional human immune system capable of generating TILs. This model is ideal for long-term studies of immuno-oncology agents.
• PBMC Humanized Mice: Utilizing adult peripheral blood mononuclear cells, these models exhibit robust TIL activity and are suitable for short-term studies. They can be customized to study specific immune cell types, such as T cells and NK cells, enhancing the understanding of TIL dynamics in cancer.

Custom Animal Model Development

Each research project might need distinct characteristics in animal models. Therefore, we offer custom animal model development services tailored to meet your unique research needs. Go and custom your animal model.

Whether you require specialized immunocompetent models, humanized mice, or PDX models, our team of experts is dedicated to collaborating with you to create the most suitable in vivo testing platform for your studies on TILs. Contact us today to discuss your requirements and accelerate your immuno-oncology research with our innovative animal models.