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Anti-GTS1 T cell receptor (D2H), pCDTCR1 (TCR-YC0517)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-GTS1 T cell receptor (TCR) is constructed for the engineering of T cell to target GTS1 peptide (GTSGSPIVNR) restricted by HLA-A*11:01. The T cells are genetically modified through transduction with a lentiviral vector expressing GTS1-specific T cell receptor.

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Details

  • Target
  • GTS1
  • Target Species
  • DENV1
  • Epitope
  • GTSGSPIVNR
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-A*11:01
  • Targeting Diseases
  • DENV infection
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • D2H
  • Host Species
  • Human

Target

  • Introduction
  • There are four serotypes of DENV (DENV1–DENV4), which differ at the amino-acid level by 30–35%. As a consequence of this heterogeneity, immunity to one serotype does not necessarily protect against infection with another serotype. Sequential infections are therefore common in DENV-endemic countries, where all four serotypes often circulate at the same time or replace each other in a cyclical manner. Epidemiological studies have further shown that adverse clinical outcomes are more frequent during secondary or recurrent infections.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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