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Anti-nef T cell receptor ((H27-14)-2), pCDTCR1 (TCR-YC0726)

The vector of anti-nef T cell receptor (TCR) is constructed for the engineering of T cell to target Nef134-10 (RYPLTFGWCF) restricted by HLA-A24. The T cells are genetically modified through transduction with a lentiviral vector expressing nef-specific T cell receptor.

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Details

  • Target
  • nef
  • Target Species
  • HIV1
  • Epitope
  • RYPLTFGWCF
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-A24
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • H27-14
  • Host Species
  • Human

Target

  • Introduction
  • Nef134-10 epitope (RYPLTFGWCF) was a highly immunogenic epitope restricted by HLA-A24. Y135F was the major escape mutation which appeared early in the clinical course. Y135F was a processing mutation was later confirmed by others. HIV-1 with Y135F mutation has been accumulating in the population with high HLA-A24 prevalence such as Japanese. Hence, Y135F is the ultimate escape mutation which appears early in the clinical course. F139L was a minor but also HLA-A24-related mutation. Intriguingly, all 6 patients with F139L mutation kept the wild type residue at 135th position in the epitope.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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