CellRapeutics™ Leukopak from Graves' Disease Donor (XS-0426-XU240)

Name: CellRapeutics™ Leukopak from Graves' Disease Donor
SKU: XS-0426-XU240
Rating: 5 (1 reviews)

Online Inquiry Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This Leukopak is derived from donors with Graves' Disease, reflecting a state of thyroid-specific humoral autoimmunity. The cells include a high frequency of B-cell clones producing Thyroid Stimulating Immunoglobulins and T-cell subsets that drive orbital and thyroid tissue remodeling. It is an invaluable resource for investigating the breakdown of self-tolerance in the thyroid-pituitary axis and the systemic drivers of hyperthyroidism.

Specific Inquiry

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Donor Information

Product Name
CellRapeutics™ Leukopak from Graves' Disease Donor

Cat. No.
XS-0426-XU240

Donor Age
Young Adult, Middle-Aged

Donor Health
Donors present with thyroid-targeted autoimmunity. The immune population is marked by B-cell hyperactivity and specific T-cell subsets that contribute to thyroid-stimulating immunoglobulin production.

Ethnicity
Diverse backgrounds available.

Anticoagulant
Acid Citrate Dextrose, optimized to preserve thyrotropin receptor-specific B/T cell interactions and maintain cellular viability.

Additional Donor Information
Each lot features a Leukopak from donors with autoimmune hyperthyroidism. Profiles include TSI titers and thyroid function tests, supporting studies on B and T cell dysregulation in thyroid autoimmunity.

Clinical Profile
Thyroid function status, presence of orbitopathy, and history of anti-thyroid medications or radioactive iodine.

Additional Information

Medication History
Available upon request. Documentation of antithyroid medications, beta-blockers, and history of radioactive iodine treatment.

Formulation
Cryopreserved or Fresh options available.

Cell Purity
>90%

Cell Viability
>90%

Mycoplasma Testing
Negative

Sterility Testing
Negative

Genetic Stability Testing
The donor cells maintain their native genetic profile, exhibiting no karyotypic abnormalities or chromosomal instabilities typically associated with prolonged ex vivo expansion.

Application
Drug Discovery, Immuno-oncology Research

Research Use Only
RUO

Quality Control
Each product batch is strictly validated for high cellular viability, specific immune cell counts, and pathogen-free safety, ensuring consistent clinical phenotypes and ethical compliance for advanced immunological research.

Storage
Store fresh Leukopaks at 2°C to 8°C for immediate use, cryopreserved samples must be kept in liquid nitrogen vapor phase below -150°C.

Shiping
Dry Ice

Handling Notes
Process fresh cells within 48 hours or perform rapid thawing of cryovials in a 37°C water bath followed by gradual dilution to maximize recovery.

Warnings
Treat as potentially biohazardous human-derived material and handle strictly under BSL-2 guidelines using appropriate personal protective equipment.

Size
Full Bag, Half Bag

Keywords
CellRapeutics™ Leukopak from Graves' Disease Donor, Leukopak, Graves' Disease

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.