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Anti-KRAS T cell receptor, pCDTCR1 (TCR-ZP012)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-KRAS T cell receptor (TCR) is constructed for the engineering of T cell to target Human KRAS. The T cells are genetically modified through transduction with a lentiviral vector expressing KRAS-specific T cell receptor. And the vector product was designed for the treatment of Pancreatic cancer, Colorectal cancer.

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Details

  • Target
  • KRAS
  • Target Species
  • Human
  • Epitope
  • VVVGADGVGK
  • Format
  • Modified TCR
  • Allele
  • HLA-A0301
  • Targeting Diseases
  • Pancreatic cancer, Colorectal cancer
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • CBL-Z009
  • Host Species
  • Human

Target

  • Official Symbol
  • KRAS
  • Introduction
  • This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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