Anti-LMP2 T cell receptor, pCDTCR1(TCR-C112Z)

The vector of anti-LMP2 T cell receptor (TCR) is constructed for the engineering of T cell to target EBV LMP2. The T cells are genetically modified through transduction with a lentiviral vector expressing LMP2-specific T cell receptor. And the vector product was designed for the treatment of Hodgkin's disease.


Details


Target
LMP2
Target Species
EBV
Epitope
CLGGLLTMV
Format
Murinized and Codon-optimized and Cysteine-modi?ed
HLA
HLA-A2
Targeting Diseases
Hodgkin's disease
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Host
Murinized

Target


Gene Name
EBNA3A nuclear protein
Official Symbol
LMP2
UniProt ID
Synonyms
CT1.10; MAGE10; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Melanoma
Introduction
Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2) are two viral proteins of the Epstein–Barr virus. LMP2A/LMP2B are transmembrane proteins that act to block tyrosine kinase signaling. LMP2A is a transmembrane protein that inhibits normal B-cell signal transduction by mimicking an activated B-cell receptor (BCR). The N-terminus domain of LMP2A is tyrosine phosphorylated and associates with Src family protein tyrosine kinases (PTKs) as well as spleen tyrosine kinase (Syk). PTKs and Syk are associated with BCR signal transduction.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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LymphomaViral InfectionCarcinoma

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