Lenti-Nef TCR (HIV-A3-QK10-5)-VP(VP-TCR-C326)
The ready-to-use lentiviral particles of Lenti-Nef TCR (HIV-A3-QK10-5)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of Human TCR will be driven by a CMV promotor. The target gene of TCR packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.
Specifications
Type of Therapeutics
T cell receptor
Packaging System
Lentivirus
Targeting Diseases
HIV infection
Target
Introduction
The HIV Nef protein is a multifunctional virulence factor that perturbs intracellular membranes and
signalling and is secreted into exosomes. While Nef-containing exosomes have a distinct proteomic
profile, no comprehensive analysis of their miRNA cargo has been carried out. Since Nef functions as a
viral suppressor of RNA interference and disturbs the distribution of RNA-induced silencing complex
proteins between cells and exosomes, we hypothesized that it might also affect the export of miRNAs
into exosomes
Alternative Names
CTAG1A; CT6.1; CTAG; Cancer/Testis Antigen 6.1; Cancer/Testis Antigen 1; Autoimmunogenic Cancer/Testis Antigen NY-ESO-1; CTAG1; LAGE2A; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Melanoma
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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Datasheet
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