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Lenti-Nef TCR (HIV-A3-QK10-5)-VP(VP-TCR-C326)

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The ready-to-use lentiviral particles of Lenti-Nef TCR (HIV-A3-QK10-5)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of Human TCR will be driven by a CMV promotor. The target gene of TCR packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.

Specifications

Type of Therapeutics
T cell receptor
Target
Nef
Clone
HIV-A3-QK10-5
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
HIV infection

Target

Introduction
The HIV Nef protein is a multifunctional virulence factor that perturbs intracellular membranes and
signalling and is secreted into exosomes. While Nef-containing exosomes have a distinct proteomic
profile, no comprehensive analysis of their miRNA cargo has been carried out. Since Nef functions as a
viral suppressor of RNA interference and disturbs the distribution of RNA-induced silencing complex
proteins between cells and exosomes, we hypothesized that it might also affect the export of miRNAs
into exosomes
Alternative Names
CTAG1A; CT6.1; CTAG; Cancer/Testis Antigen 6.1; Cancer/Testis Antigen 1; Autoimmunogenic Cancer/Testis Antigen NY-ESO-1; CTAG1; LAGE2A; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Melanoma
Gene ID
156110

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

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