Get a real taste and understanding of the business and culture of one of the world's great research-based cellular and gene therapy discovery and development companies.
EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsTo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
Scientific advances in cryopreservation have enabled the prospect of establishing "living biobanks" that store viable, functional tissue or replicable cell types for years to decades. This could have a significant impact across basic biological research, medicine, and the biopharma industry. Living biobank allows for the delivery of de-identified clinical data. With our state-of-the-art technology and seasoned expertise, Creative Biolabs has perfected our technical pipelines in the establishment of living tumor biobanking. A targeted but scalable workflow can be adjusted to accommodate a variety of research needs. Living tumor biobank will constitute an important tool for functional personalized medicine for cancers, especially chimeric antigen receptor (CAR)-engineered T-cell therapy preclinical study. Our multidisciplinary platform teams work closely to address these scientific and technical challenges.
Cancer research is a complex field and now focused on a personalized medicine approach. Researchers aim to understand how different tumor types change on a molecular level over time. Clinicians have the goal to develop tailored treatment plans for individual patients. Living cancer biobanks play a key role in this research by collecting, processing, storing, and distributing patient samples and associated data. Successful development of effective treatments relies heavily on experimental models predictive of clinical outcomes. Patient-derived xenografts (PDXs) have long been regarded as the model of choice to test chemo- and/or targeted therapies for close mimicking human disease and heterogeneous patient population. Over the last few years, tens of thousands of PDXs have become a workhorse for cancer drug evaluation in the preclinical setting.
Fig.1 Personalized models to guide precision medicine in advanced cancer. (Pauli, 2017)
Specimens are collected from patients meeting inclusion criteria. Tumor tissues from surgical resections include diverse cancer types, such as lung cancer, gastric cancer, colorectal cancer, pancreatic cancer, breast cancer, esophageal cancer, ovarian cancer, head&neck cancer, cervical cancer, mesothelioma, and metastatic cancer. Collaborated with hospital and researchers, Creative Biolabs has establishes large PDX libraries (>1700 PDX models) covering a range of tumor types. Many PDXs have been extensively tested for various investigational therapies, such as CAR-T therapy research, other immunology research, and infectious disease research.
Creative Biolabs is well equipped and versed in employing living biobanks to advance CAR-T research. By leveraging the wealth of knowledge that we have on each tumor model, Creative Biolabs is happy to provide suggested PDX models to help you with our clients' valuable preclinical study. All our services are customized. Contact us to know more, we are looking forward to hearing from you.
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NEWSLETTER
The latest newsletter to introduce the latest breaking information, our site updates, field and other scientific news, important events, and insights from industry leaders
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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