pCDCAR1 TAG-72 h(28), T (CAR-T-1-M551-2)

The vector of anti-TAG-72 chimeric antigen receptor(CAR) is constructed for the engineering of T cell to target human TAG-72. The T cell is genetically modified through transduction with a lentiviral vector expressing anti-TAG-72 VHH linked to VHH-CD28 signaling domains. And the vector product was designed for the treatment of TAG-72 expressing tumor.

Datasheet   Add to Cart


  • Target
  • TAG-72
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • TAG-72 expressing tumor
  • Generation
  • First
  • Vector Name
  • pCDCAR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Receptor Construction
  • VHH-CD28
  • Discription of Signaling Cassetes
  • CD28
    CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatorysignals required for T cell activation and survival. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins which are expressed on antigen-presenting cells(APC). CD28 modulates the primary TCR/CD3ζ signal in a different fashion than the late costimulatory elements OX40 and 4-1BB. CD28 enhances the expression of downstream regulators that impact on T-cell proliferation, death, differentiation, and effector functions. CAR+ T cells containing the CD28 endodomain showed strikingly enhanced sustained T cell activation, growth, survival. And CD28 results in a brightly expressed, stable receptor as the transmembrane domain. Including CD28 costimulatory domains in CARs led to enhanced anti-malignancy efficacy.


  • Clone
  • CC49
  • Host
  • Humanized
  • Target Species
  • Human
  • Gene Name
  • TAG-72
  • Synonyms
  • TAG-72;

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products

All services and products are only for lab research use, not for any clinical diagnosis or treatment.

Online Inquiry

For any technical issues or products/services related questions, please leave your information below. Our team will contact you soon.

  • Verification code
    Click image to refresh the verification code.

Key Updates

Receive our latest news and insights.