VivoCAR™ Anti-CCR8 (7-B16) h(CD28-41BB-CD3z) CAR circRN (XS-1225-YX104)

Name: VivoCAR™ Anti-CCR8 (7-B16) h(CD28-41BB-CD3z) CAR circRN
SKU: XS-1225-YX104
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CCR8 (7-B16) h(CD28-41BB-CD3z) CAR circRNA utilizes the 7-B16 clone, optimized for its potent signaling in the low-oxygen conditions of solid tumors. In the context of in-situ cell engineering, this clone is vital for recognizing CCR8+ malignant cells in certain T-cell leukemias. The circular RNA scaffold achieves high-level CAR protein synthesis on endogenous lymphocytes, enabling a potent therapeutic window to target treatment-resistant malignancies. This non-viral strategy allows for precise administrations that ensure the eventual restoration of normal immune surveillance once the RNA payload is naturally cleared.

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Target Information

Target
CCR8

Common Name
CCR8

Alternative Names
CC-CKR-8, CCR-8, CDw198, CKRL1, CMKBR8, CMKBRL2, CY6, GPRCY6, TER1

Full Name
C-C Chemokine Receptor Type 8

Introduction
CCR8 is a G-protein-coupled receptor that binds CCL1. It is a critical marker because it is highly and selectively expressed on tumor-infiltrating regulatory T cells (Tregs) in the tumor microenvironment (TME). Tregs are primary mediators of immunosuppression in solid tumors. Targeting CCR8 aims to specifically deplete these Tregs, reversing the immunosuppression and allowing endogenous or CAR-T cells to mount an effective anti-tumor response.

Targeting Diseases
Various Solid Tumors (e.g., Breast Cancer, Ovarian Cancer, Colon Cancer)

UniProt ID
P51685

Gene ID
1237

CAR Information

Target Species
Human

Antibody Clone
7-B16

scFv-Host Species
Human

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

CAR circRNA Properties

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

circRNA Properties and Quality Control

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Case Studies

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.