VivoCAR™ Anti-CD10 (Mab3124) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX105)

Name: VivoCAR™ Anti-CD10 (Mab3124) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX105
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CD10 (Mab3124) h(CD28-41BB-CD3z) CAR circRNA utilizes the Mab3124 clone to target the common acute lymphoblastic leukemia antigen (CALLA). This product is essential for the in vivo destruction of CD10+ malignant progenitors in B-ALL. By delivering the CAR through our stable circRNA platform, we enable a transient therapeutic pulse that provides a powerful debulking effect. The non-integrating nature of the transcript ensures that the therapy naturally tapers off, preventing the risk of permanent depletion of healthy stromal cells or progenitor niches once the malignant clones are eradicated.

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Target Information

Target
CD10

Common Name
CD10

Alternative Names
NEP, SFE, MME, CALLA, CMT2T, SCA43

Full Name
Cluster of Differentiation 10

Introduction
CD10 is a cell-surface metalloprotease (neutral endopeptidase) primarily expressed on early lymphoid and myeloid progenitor cells. It is known as the Common Acute Lymphoblastic Leukemia Antigen (CALLA) due to its high expression on the majority of B-cell Acute Lymphoblastic Leukemia (B-ALL) cells. CD10 is used as a diagnostic marker for ALL and is an attractive therapeutic target, especially in CD19-negative relapses, to achieve deeper molecular remission.

Targeting Diseases
B-cell Acute Lymphoblastic Leukemia (B-ALL), Follicular Lymphoma, Myeloid Leukemia

UniProt ID
P08473

Gene ID
4311

Target Species
Human

Antibody Clone
Mab3124

scFv-Host Species
Mouse

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

VivoCAR™ Anti-CD10 (Mab3124) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX105)

Target Information

Customer Reviews and Q&As

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