VivoCAR™ Anti-FAP (NI-206.82C2) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX39)

Name: VivoCAR™ Anti-FAP (NI-206.82C2) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX39
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-FAP (NI-206.82C2) h(CD28-41BB-CD3z) CAR circRNA utilizes the NI-206.82C2 clone to achieve precision-guided remodeling of the tumor stroma. By targeting FAP-positive fibroblasts directly in vivo, this product facilitates the physical dismantling of the protective extracellular matrix that shields solid tumors from immune infiltration. The circRNA platform ensures a potent yet self-limiting therapeutic window, empowering the host's T cells to "clear the path" for subsequent therapies without causing permanent damage to healthy wound-healing processes or bone marrow-derived stromal cells.

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Target Information

Target
FAP

Common Name
FAP

Alternative Names
FAPA, SIMP, DPPIV, FAPalpha

Full Name
Fibroblast Activation Protein alpha

Introduction
FAP is a cell surface serine protease highly and selectively expressed by Cancer-Associated Fibroblasts (CAFs) in the tumor stroma of over 90% of solid tumors. CAFs promote tumor growth, immune evasion, and drug resistance. Targeting FAP aims to remodel the immunosuppressive tumor microenvironment (TME) rather than killing tumor cells directly.

Targeting Diseases
Virtually all Solid Tumors (e.g., Pancreatic, Lung, Colorectal, Breast Cancer)

UniProt ID
Q12884

Gene ID
2191

Target Species
Human

Antibody Clone
NI-206.82C2

scFv-Host Species
Human

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

VivoCAR™ Anti-FAP (NI-206.82C2) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX39)

Target Information

Customer Reviews and Q&As

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