APRPG Pep-LNP
Cat. No.: TDLD-0825-LD89
APRPG Pep-LNP
APRPG Pep-LNP is a state-of-the-art peptide-functionalized lipid nanoparticle (LNP), designed for efficient targeted delivery of therapeutic cargoes such as siRNA, mRNA, DNA, small molecule drugs, and RNA-guided gene editing systems, particularly to the tumor microenvironment. Engineered with the APRPG peptide, a five-amino acid tumor neovasculature-targeting peptide that specifically binds to newly formed blood vessels in tumors, this LNP facilitates enhanced accumulation of the therapeutic payload at the tumor site by homing to the angiogenic vasculature. Our LNP is prepared using Targeting Module and a variety of optional lipid formulations including DLin-MC3-DMA, LP-01, ALC-0315, SM102, and others. These formulations are carefully selected to ensure the LNP has uniform particle size, high encapsulation efficiency, stability, and targeted delivery. Applications of APRPG Pep-LNP include research in anti-angiogenic cancer therapy, tumor imaging, targeted delivery of chemotherapeutics or immunotherapeutics to the tumor vasculature, and studying the biology of tumor angiogenesis. Please note that this product is intended for research purposes only.
| Payload Type | mRNA |
| Payload | Empty; EGFP mRNA; Firefly Luciferase mRNA; mCherry mRNA; GFP mRNA; OVA mRNA; EPO mRNA; Renilla Luciferase mRNA; Gaussia Luciferase mRNA; Beta-galactosidase mRNA; Cre mRNA; mOrange mRNA; tdTomato mRNA; EYFP mRNA; Others |
| Capping | Cap 1 |
| Modification | Unmodified; N1-methyl-pseudouridine; 5-methoxyuridine; Other |
| Module Type | Peptide |
| Targeting Module | APRPG Peptide |
| LNP Type | Pep-LNP; Empty LNP; mRNA-LNP |
| Target | Tumor cells |
| Lipid Formulation | DLin-MC3-DMA; LP-01; ALC-0315; SM102; Other |
| Dye | Unlabeled; DiR; DiD; DiO; DiI; Other |
| Application | Targeted Delivery; Gene Therapy |
| Format | Liquid |
| Concentration | 0.1 mg/mL; 0.2 mg/mL; Other (Please Specify) |
| Size | 65-120 nm |
| PDI | < 0.2 |
| Zeta | ± 20.0 mV |
| Encapsulate Efficiency | >90% |
| Shipping | Dry Ice |
| Storage | Store at -80°C |
Click the button below to contact us or submit your feedback about this product.
