All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
The crystal structure of the epitope/hbMR1 complex bound to the AE6 MAIT TCR was determined. The hbMR1 is a humanized version of bovine MR1 with three mutations at residues, A72M, R147Q and Q151L, which are TCR contact positions that differ between human and bovine MR1. The hbMR1 and β2m are expressed as a single chain construct.
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