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Anti-C13H19N7O3 T cell receptor (G2), pCDTCR1 (TCR-YC0181)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The crystal structure of the epitope/hbMR1 complex bound to the AE6 MAIT TCR was determined. The hbMR1 is a humanized version of bovine MR1 with three mutations at residues, A72M, R147Q and Q151L, which are TCR contact positions that differ between human and bovine MR1. The hbMR1 and β2m are expressed as a single chain construct.

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Details

  • Target
  • C13H19N7O3
  • Epitope
  • N(6)-[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]-D-lysine
  • Format
  • Non-Modified TCR
  • Allele
  • hbMR1
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • G2
  • Host Species
  • Human

Target

  • Introduction
  • MR1-restricted mucosal-associated invariant T (MAIT) cells represent a subpopulation of T cells with innate-like properties and limited TCR diversity. MAIT cells are of interest because of their reactivity against bacterial and yeast species, suggesting that they play a role in defense against pathogenic microbes.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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