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Anti-PABPC4 T cell receptor (CH6), pCDTCR1 (TCR-YF289)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-PABPC4 T cell receptor (TCR) is constructed for the engineering of T cell to target PABPC4. The T cells are genetically modified through transduction with a lentiviral vector expressing PABPC4-specific T cell receptor. And the vector product was designed for the treatment of Cancer.

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Details

  • Target
  • PABPC4
  • Target Species
  • Human
  • Epitope
  • MLGERLFPL
  • Format
  • Non-modified
  • Allele
  • HLA-A*02:01
  • Targeting Diseases
  • Cancer
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • CH6
  • Host Species
  • Human

Target

  • Introduction
  • Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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