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CellRapeutics™ CD56+ NK Cells from Type 2 Diabetes Donor (XS-0426-XU303)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Derived from donors with Type 2 Diabetes, these CD56+ NK cells reflect the physiological impact of "metainflammation" and chronic insulin resistance. The population is often characterized by metabolic reprogramming and altered expression of activating receptors. This product serves as an ideal model for investigating how the obese and hyperglycemic environment impairs innate immunosurveillance and increases susceptibility to infection.

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Donor Information

  • Product Name
  • CellRapeutics™ CD56+ NK Cells from Type 2 Diabetes Donor
  • Cat. No.
  • XS-0426-XU303
  • Donor Age
  • Middle-Aged, Senior
  • Donor Health
  • NK cells exhibit markers of metabolic stress and chronic low-grade activation. The population reflects a state of "metabolic exhaustion," featuring reduced cytotoxic vigor and signatures of accelerated cellular aging driven by hyperinsulinemia.
  • Ethnicity
  • Diverse backgrounds available.
  • Anticoagulant
  • Heparin or Acid Citrate Dextrose, optimized to combat hyperinsulinemia-induced metabolic dysfunction and maintain NK cell mitochondrial health and viability.
  • Additional Donor Information
  • Each lot features CD56+ NK cells from donors with T2DM. Profiles include HbA1c and BMI, enabling research into the effects of chronic hyperglycemia on NK cell metabolic fitness and surveillance.
  • Clinical Profile
  • Duration of diagnosis, BMI, presence of microvascular complications and current glucose-lowering therapy history.

Additional Information

  • Medication History
  • Available upon request. Records of glycemic control medications and treatments for chronic low-grade inflammation associated with insulin resistance.
  • Formulation
  • Cryopreserved in specialized freezing medium
  • Cell Purity
  • >90%
  • Cell Viability
  • >90%
  • Mycoplasma Testing
  • Negative
  • Sterility Testing
  • Negative
  • Genetic Stability Testing
  • The donor cells maintain their native genetic profile, exhibiting no karyotypic abnormalities or chromosomal instabilities typically associated with prolonged ex vivo expansion.
  • Application
  • Drug Discovery, Immuno-oncology Research
  • Research Use Only
  • RUO
  • Quality Control
  • Each product batch undergoes rigorous testing for purity, viability, and microbial contamination.
  • Storage
  • Maintain long-term storage in liquid nitrogen vapor phase (below -150°C), avoid temperature fluctuations above -135°C to preserve NK cell lytic activity.
  • Shiping
  • Dry Ice
  • Handling Notes
  • Perform rapid thawing at 37°C and implement slow, dropwise dilution with pre-warmed media to minimize osmotic stress and ensure optimal cell recovery.
  • Warnings
  • Treat as potentially biohazardous human-derived material and handle strictly under BSL-2 guidelines using appropriate personal protective equipment.
  • Size
  • 5E6 cells/vial, 1E7 cells/vial
  • Keywords
  • CellRapeutics™ CD56+ NK Cells from Type 2 Diabetes Donor, CD56+ NK Cells, Type 2 Diabetes

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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