ActivatorPep™ SARS-CoV-2 Prot_S P.1, Mut (CA-LX145)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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Product Name
ActivatorPep™ SARS-CoV-2 Prot_S P.1, Mut

Cat. No.
CA-LX145

Product Summary
Creative Biolabs provides an extensive cell activation reagents including Expansion Kits and Activator peptides for global custom, which are suitable to many applications, such as in vitro stimulation antigen-specific cells. SARS-CoV-2 Prot_S P.1 are pools of lyophilized peptides, consisting mainly of 15-mer sequences with 11 amino acids overlap. The SARS-CoV-2 Prot_S P.1 Mutation Pool covers selectively the mutated regions in the surface or spike glycoprotein ("S") of the SARS-CoV-2 P.1 lineage. Which can be used for in vitro stimulation of SARS-CoV-2-specific CD4+ and CD8+ T cells.

Background Information
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) was first detected in December 2019 in Wuhan, China. Since that time the virus kept mutating, leading to new virus variants. The B.1.427/B.1.429 lineage, also known as CAL.20C or GH/452R.V1, is a SARS-CoV-2 variant that was first discovered in Southern California, US in July 2020. The mutations of this variant affect also immune-relevant parts of structural SARS-CoV-2 proteins and the respective sequences are available in GISAID, a genome data base. The mutations listed below are taken from sequence EPI_ISL_648527. The B.1.427/B.1.429 lineage has been found to evade a pre-existing antibody response and appears to be more infectious than other variants. In total there are 4 mutations in surface or spike glycoprotein ("S") of the B.1.427/B.1.429 lineage compared to the Wuhan variant (reference genome GenBank MN908947.3): S13I, W152C, L452R and D614G.

Applications
Stimulation Reagents

Cross-reactivity
No significant cross-reactivity was observed among analytes in this panel.

Species Reactivity
Human

Purity or Quality Grade
Research Grade

Downstream Application
Pulsing of antigen-presenting cells for research;
Detection and analysis of antigen-specific CD4+ and CD8+ effector/memory T cells in PBMCs;

Product Size
for stimulation of 1×108 cells

Shipping Condition
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Storage Conditions
Store at -20°C.

Shelf life
> 6 Months from date of receipt under proper storage condition.

Product Use Statement
For research use only, not for diagnostic or therapeutic use.

Product Features
Efficient expansion and increased survival rate of Ag-specific T cells;
Provides a gentle activation stimulus that maintains high viability of activated and expanded T cells;

Principle of the Assay
In vitro stimulation of antigen-specific T cells with Peptide Pools causes the secretion of effector cytokines and the up-regulation of activation markers, which then allow the detection and isolation of antigen-specific T cells.

Research Category
Immunology

Panel Type
Stimulation for CD4+ and CD8+ T cells

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

ActivatorPep™ SARS-CoV-2 Prot_S P.1, Mut (CA-LX145)

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