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Anti-COL18A1 T cell receptor, pCDTCR1 (TCR-ZP436)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-COL18A1 T cell receptor (TCR) is constructed for the engineering of T cell to target Human. The T cells are genetically modified through transduction with a lentiviral vector expressing COL18A1-specific T cell receptor. And the vector product was designed for the treatment of Breast cancer.

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Details

  • Target
  • COL18A1
  • Target Species
  • Human
  • Epitope
  • VLLGVKLSGV
  • Format
  • Non-modified
  • Allele
  • HLA-A2
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Breast cancer
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • H19
  • Host Species
  • Human

Target

  • Introduction
  • This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple helix domains (collagenous domains) interrupted by non collagenous domains. A long isoform of the protein has an N terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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