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A iNKG2D.YA-CAR [iNKG2D.YA-BBζ], with a CAR Adaptor [Anti-HIV MicAb (0PV-c.01)], a convertibleCAR System (CAR-NR-LX196)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The convertibleCAR system is based on the mechanism: engineering of a privileged receptor-ligand (iNKG2D.YA and MIC ligand) pairing comprising human components for a highly adaptable CAR, resulting in a versatile and broadly controllable platform. An inert form of the human NKG2D extracellular domain (iNKG2D) was engineered as the ectodomain of the CAR linked to 4-1BB and CD3ζ signaling domains. The MicAb CAR adaptor was engineered with a HIV antibody (clone 0PV-c.01) and a MIC ligand, which is capable of directing and activating iNKG2D-CAR-expressing T cells only when the appropriate antigen is displayed on a surface. And the product was designed for the treatment of AIDS.

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CAR Schemeitc

UniCAR

  • CAR Construction
  • iNKG2D.YA-41BB-CD3ζ-eGFP
  • Discription of Signaling Cassetes
  • 41BB
    CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigennonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric 4-1BB and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
  • Vector Name
  • pCDCAR1
  • Vector length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Targeting Diseases
  • AIDS

CAR Adaptor

  • Common Name
  • Glycoprotein gp120
  • Adaptor Type
  • Mic Antibody
  • Antibody Host
  • Macaque
  • Antibody Clone
  • 0PV-c.01
  • CAR Adaptor Tag
  • MIC Ligand

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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