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The vector of anti-TRIP11 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human TRIP11. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-TRIP11 antibody linked to 4-1BB (CD137) and CD3ζ signaling domains. And the vector product was designed for the treatment of Breast cancer.
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Details
Target
TRIP11
Epitope
aa 1099-1372
Targeting Cell Type
T cell
Targeting Diseases
Breast cancer
Generation
Second
Vector Name
pCDCAR1
Vector Length
~8kb
Vector Type
Lentiviral vector
Receptor Construction
scFv-41BB-CD3ζ
Discription of Signaling Cassetes
41BB CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigen-nonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity. CD3ζ CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta,which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
Thyroid Hormone Receptor Interactor 11; Clonal Evolution-Related Gene On Chromosome 14 Protein; Golgi-Associated Microtubule-Binding Protein 210; TR-Interacting Protein 11; GMAP-210; TRIP230; TRIP-11;
Introduction
TRIP11 was identified based on the interaction of its protein product with thyroid hormone receptor beta. TRIP11 is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to function in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in TRIP11 cause achondrogenesis type IA.
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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