Lymphoma-Specific CAR Construction Service

Are you currently facing long drug development cycles, challenges in CAR-T/NK cell engineering, or difficulty in achieving high specificity and persistence for your lymphoma therapies? Our lymphoma-specific CAR construction service helps you accelerate immunotherapy development, obtain highly specific and potent CAR constructs, and streamline preclinical research through advanced genetic engineering, high-throughput screening platforms, and innovative cell engineering techniques.

Introduction

Lymphoma is a class of cancer that affects the lymph system. The two main types of lymphoma are described as Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL), respectively. Chemotherapy, radiation therapy, biologic therapy or a combination of these therapies are often used in the treatment of lymphoma. But these traditional approaches always have long-term side effects. In the last decade, CAR-T cell therapy has become a promising field for lymphoma treatment, which can overcome certain drawbacks. With the most advanced techniques, our experienced scientists can provide highly customized service for CARs production, which can greatly promote your research progress.

Lymphoma-Specific CAR Construction Service at Creative Biolabs

Our lymphoma-specific CAR construction service provides comprehensive solutions tailored to your unique research and development needs. We assist in the precise identification of optimal target antigens, design and engineer cutting-edge CAR constructs, and ensure the efficient and stable integration of these CARs into T or NK cells. Our expertise specifically addresses critical challenges such as overcoming antigen escape mechanisms by designing multi-targeted CARs, enhancing CAR cell persistence through advanced "arming" strategies like cytokine co-expression (e.g., IL-21 for CAR-NK cells), and minimizing off-target toxicities by fine-tuning CAR affinity and specificity. We deliver functionally validated CAR constructs ready for your preclinical studies, significantly de-risking your therapeutic development pipeline.

Service Process

Key Advantages

• Expert CAR Design & Optimization: Leverage deep CAR biology knowledge to design lymphoma-specific CARs, optimizing all modules (ligand affinity, signaling domains) by accounting for epitope location, tonic signaling, and kinetic segregation. Bespoke designs match targets and goals.
• Diverse CAR Formats: multi-targeted (anti-antigen escape), armored (e.g., IL-21 for NK persistence), conditional (safety/control), inhibitory (specificity), universal/switchable (flexible targeting).
• Rigorous Quality Control & Validation: Stringent quality assurance at all stages: gene synthesis, high-purity vectors, functional testing (cytotoxicity, cytokines, proliferation). Adheres to quality-by-design and process analytical techniques for reliability.

Typical data

Summary: In this study, CD19-specific CAR-NK cells expressing IL-21 or IL-15 were constructed, and their characteristics were compared. Results showed that CAR-21 (expressing IL-21) significantly increased the production of IFN-γ, TNF-α, and granzyme B as well as degranulation in response to CD19⁺ Raji lymphoma cells, with stronger cytotoxicity upon repeated stimulation. In xenograft models, CAR-21 exhibited enhanced in vivo persistence, more significant suppression of tumor growth, and prolonged survival of mice. RNA sequencing revealed enrichment in cytokine, cytotoxicity, and metabolism-related signaling pathways.

Fig.1 Evaluation of CAR-NK cell cytotoxicity.¹

FAQs

Why Choose Us?

At Creative Biolabs, our lymphoma-specific CAR construction service is meticulously designed to provide you with unparalleled support and cutting-edge solutions for your immunotherapy research. We are committed to delivering customized, high-quality CAR constructs that accelerate your path to discovery and therapeutic development.

Customer Reviews

"Creative Biolabs' armored CAR-NK cell constructs, particularly those co-expressing IL-21, have revolutionized our in vivo studies. We observed dramatically improved persistence and anti-tumor efficacy in our lymphoma models compared to standard CAR-NK designs. This service has directly accelerated our preclinical validation, demonstrating their deep understanding of NK cell biology and cytokine engineering." - July 2025, Dr. L. Mar***

"The comprehensive consultation and efficient workflow provided by Creative Biolabs were exceptional. They helped us navigate complex multi-target CAR designs and delivered high-quality constructs and functional data much faster than we could achieve in-house. Their service is a game-changer for academic research groups like ours, offering expertise far beyond what typical core facilities can provide." - June 2025, Prof. A. Bro***

How to Contact Us

Ready to revolutionize your lymphoma immunotherapy project? Our expert team is eager to discuss your specific needs and provide tailored solutions. Connect with our team for additional information and to deliberate on your project.

Products against Lymphoma-specific antigens

Based on targeting different Lymphoma antigens, we can provide a variety of world leading CARs production service as listed in the table below. Meanwhile, Creative Biolabs is pleased to announce that we can also offer bespoke service to meet various requirements from our customers. Please feel free to contact us.

Reference

1. He, Bailin et al. "Interleukin-21 engineering enhances CD19-specific CAR-NK cell activity against B-cell lymphoma via enriched metabolic pathways." Experimental hematology & oncology vol. 14,1 51. 2 Apr. 2025, https://doi.org/10.1186/s40164-025-00639-2. Distributed under Open Access License CC BY 4.0, without modification.