FITC-labeled Human GUCY2C CAR Detection Reagent, His Tag (CARD-LX125)

Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Evaluating CAR expression is an essential step in the production of CAR-T cells. Creative biolabs provides several detection reagents which are uniquely suitable for evaluation of CAR expression. FITC-labeled Human GUCY2C CAR Detection Reagent, His Tag is a special detection reagent which is used to detect Human GUCY2C CAR related to the study of colorectal cancer.

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Specifications

Target
GUCY2C

Application
FC, ELISA

Purity
>90%

Endotoxin Level
Less than 1.0 EU per μg by the LAL method.

Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please protect from light and avoid repeated freeze-thaw cycles.

Application Notes
The optimal working dilutions should be determined by the end user.

Diseases
colorectal cancer

Molecular Characterization
It contains AA Ser 24 - Gln 430 (Accession # P25092-1).

Conjugation
FITC

Size
0.2 mg

Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Expression
Human HEK293 cells

Host Species
Human

Species Reactivity
Human

Form
lyophilized

Images
Figure 1 Structure

Figure 2 Binding activity Evaluation

Target

Target Introduction
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.

Target Alternative Names
GUCY2C

UniProt ID
P25092-1

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

FITC-labeled Human GUCY2C CAR Detection Reagent, His Tag (CARD-LX125)

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Specifications

Target

Customer Reviews and Q&As

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Protein

CAR mRNA