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DLAT

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DLAT is a component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-YC0513 Anti-DLAT (15B143) h(scFv-41BB-CD3ζ) CAR, pCDCAR1 Human 15B143 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YC0514 Anti-DLAT (4A4-B6-C10) h(scFv-41BB-CD3ζ) CAR, pCDCAR1 Human 4A4-B6-C10 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YC0515 Anti-DLAT (CBYCD-296) h(scFv-41BB-CD3ζ) CAR, pCDCAR1 Human CBYCD-296 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YC1413 Anti-DLAT (15B143) h(scFv-CD28-CD3ζ) CAR, pCDCAR1 Human 15B143 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YC1414 Anti-DLAT (4A4-B6-C10) h(scFv-CD28-CD3ζ) CAR, pCDCAR1 Human 4A4-B6-C10 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-YC1415 Anti-DLAT (CBYCD-296) h(scFv-CD28-CD3ζ) CAR, pCDCAR1 Human CBYCD-296 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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