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EBNA1

The Epstein-Barr virus (EBV), also called human herpesvirus 4 (HHV-4), is one of eight known viruses in the herpes family, and is one of the most common viruses in humans. EBV infects B cells of the immune system and epithelial cells. Once EBV's initial lytic infection is brought under control, EBV latency persists in the individual's B cells for the rest of the individual's life. EBNA-1 protein plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase, the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication, oriP. Additionally, it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally, it can counteract the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival.

Associated Disease
  • EBV infection
  • CAR Vector Products
  • TCR Vector Products
  • TCR Viral Particles
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  • Antibody Clone:
  • Receptor Construction:
CAT Product Name Target SpeciesAntibody CloneAntibody HostReceptor ConstructionVector TypeTargeting Cell Type Inquiry & Datasheet
CAR-ZP8733 Anti-EBNA1 (10C124) h(4-1BB-CD3ζ) CAR, pCDCAR1 EBV 10C124 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8734 Anti-EBNA1 (7E124) h(CD28-CD3ζ) CAR, pCDCAR1 EBV 7E124 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8735 Anti-EBNA1 (7E124) h(4-1BB-CD3ζ) CAR, pCDCAR1 EBV 7E124 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8736 Anti-EBNA1 (2Q1914) h(CD28-CD3ζ) CAR, pCDCAR1 EBV 2Q1914 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8737 Anti-EBNA1 (2Q1914) h(4-1BB-CD3ζ) CAR, pCDCAR1 EBV 2Q1914 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8738 Anti-EBNA1 (M5042521) h(CD28-CD3ζ) CAR, pCDCAR1 EBV M5042521 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8739 Anti-EBNA1 (M5042521) h(4-1BB-CD3ζ) CAR, pCDCAR1 EBV M5042521 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8740 Anti-EBNA1 (1EB12) h(CD28-CD3ζ) CAR, pCDCAR1 EBV 1EB12 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8741 Anti-EBNA1 (1EB12) h(4-1BB-CD3ζ) CAR, pCDCAR1 EBV 1EB12 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8742 Anti-EBNA1 (3EB7) h(CD28-CD3ζ) CAR, pCDCAR1 EBV 3EB7 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8743 Anti-EBNA1 (3EB7) h(4-1BB-CD3ζ) CAR, pCDCAR1 EBV 3EB7 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8730 Anti-EBNA1 (10C123) h(CD28-CD3ζ) CAR, pCDCAR1 EBV 10C123 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8731 Anti-EBNA1 (10C123) h(4-1BB-CD3ζ) CAR, pCDCAR1 EBV 10C123 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8732 Anti-EBNA1 (10C124) h(CD28-CD3ζ) CAR, pCDCAR1 EBV 10C124 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet

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