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FBXW7

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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-CQ0872 Anti-FBXW7 (FBOX 3a9/1) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse FBOX 3a9/1 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0873 Anti-FBXW7 (SP237) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat SP237 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0874 Anti-FBXW7 (CBXF-1256) h(41BB-CD3ζ) CAR, pCDCAR1 Human, Mouse CBXF-1256 Rabbit scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0875 Anti-FBXW7 (3D1) h(41BB-CD3ζ) CAR, pCDCAR1 Human 3D1 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0876 Anti-FBXW7 (CBXF-0426) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-0426 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0877 Anti-FBXW7 (CBXF-3570) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-3570 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0878 Anti-FBXW7 (CBXF-0427) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-0427 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0879 Anti-FBXW7 (13H4) h(41BB-CD3ζ) CAR, pCDCAR1 Human 13H4 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0880 Anti-FBXW7 (4C11) h(41BB-CD3ζ) CAR, pCDCAR1 Human 4C11 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0881 Anti-FBXW7 (CBXF-3766) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-3766 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0882 Anti-FBXW7 (CBXF-1413) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-1413 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0883 Anti-FBXW7 (6B1) h(41BB-CD3ζ) CAR, pCDCAR1 Human 6B1 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0884 Anti-FBXW7 (CBXF-3640) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-3640 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0885 Anti-FBXW7 (CBXF-2578) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-2578 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0886 Anti-FBXW7 (CBXF-0428) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-0428 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0887 Anti-FBXW7 (CBXF-0425) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-0425 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ0888 Anti-FBXW7 (CBXF-2915) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBXF-2915 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4296 Anti-FBXW7 (FBOX 3a9/1) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse FBOX 3a9/1 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4297 Anti-FBXW7 (SP237) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse, Rat SP237 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CQ4298 Anti-FBXW7 (CBXF-1256) h(CD28-CD3ζ) CAR, pCDCAR1 Human, Mouse CBXF-1256 Rabbit scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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