PDGFRB

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia.
  • AbTCR Vector Products

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CAT Product Name Target Species Antibody Clone Fab-Host Animal Vector Type Targeting Cell Type Inquiry & Datasheet
XS-0722-ZP4019 Anti-PDGFRB X CD3 BsAb Secreting T Cell Redirecting Vector (PDGFRBxCD3) Human T Cells   Add to Cart   Datasheet
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