TGFB2

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This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
XS-1222-ZP1192 TGFB2 (TGFBR1 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human TGFB2-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1193 TGFB2 (TGFBR2 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human TGFB2-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1194 TGFB2 (TGFBR3 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human TGFB2-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2592 TGFB2 (TGFBR1 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human TGFB2-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2593 TGFB2 (TGFBR2 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human TGFB2-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2594 TGFB2 (TGFBR3 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human TGFB2-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
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