TNFSF11

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]

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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
XS-1222-ZP1209 TNFSF11 (TNFRSF11A Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human TNFSF11-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1210 TNFSF11 (TNFRSF11B Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human TNFSF11-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2609 TNFSF11 (TNFRSF11A Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human TNFSF11-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2610 TNFSF11 (TNFRSF11B Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human TNFSF11-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
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