TNFSF12

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
XS-1222-ZP1211 TNFSF12 (TNFRSF12A Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human TNFSF12-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1212 TNFSF12 (TNFRSF25 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human TNFSF12-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2611 TNFSF12 (TNFRSF12A Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human TNFSF12-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP2612 TNFSF12 (TNFRSF25 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human TNFSF12-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
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