VivoCAR™ Anti-ERBB3 (MOR10701) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX38)

Name: VivoCAR™ Anti-ERBB3 (MOR10701) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX38
Rating: 5 (1 reviews)

Online Inquiry Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-ERBB3 (MOR10701) h(CD28-41BB-CD3z) CAR circRNA features the high-affinity MOR10701 clone, optimized for the detection of HER3 overexpression in the absence of ligand stimulation. The importance of the MOR10701 clone for in vivo CAR-T therapy lies in its exceptional sensitivity to low-density receptors on dormant metastatic cells. Combined with the high stability of the circRNA scaffold, this product allows for a sustained, systemic "patrol" by endogenous T cells, providing a safe and transient method to purge micro-metastatic niches while avoiding the long-term toxicities of genomic modification.

Add to Cart

Target Information

Target
ERBB3

Common Name
ERBB3

Alternative Names
HER3, FERLK, LCCS2, VSCN1, ErbB-3, c-erbB3, erbB3-S, MDA-BF-1, c-erbB-3, p180-ErbB3, p45-sErbB3, p85-sErbB3

Full Name
erb-b2 Receptor Tyrosine Kinase 3

Introduction
ERBB3 is a member of the ErbB family of receptor tyrosine kinases. Uniquely, it possesses impaired kinase activity but is the preferred dimerization partner for other ErbB family members (especially ERBB2/HER2). Its heterodimerization drives potent survival and proliferation signals (via the PI3K/Akt pathway) in cancer, making it a critical node for acquired resistance to ERBB-targeted therapies.

Targeting Diseases
Breast Cancer, Lung Cancer, Ovarian Cancer, Colorectal Cancer, Melanoma

UniProt ID
P21860

Gene ID
2065

Target Species
Human

Antibody Clone
MOR10701

scFv-Host Species
Human

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Customer Reviews and Q&As

There are currently no customer reviews or questions for VivoCAR™ Anti-ERBB3 (MOR10701) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX38). Click the button below to contact us or submit your feedback about this product.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

VivoCAR™ Anti-ERBB3 (MOR10701) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX38)

Target Information

Customer Reviews and Q&As

Related Products

CAR Vector Products

CAR mRNA

CAR Cell Products

TriCAR Vector Products

CAR Animal Cells

CAR Viral Particles