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A uniCAR [Anti-FITC scFv-BBζ], with a CAR Adaptor [Anti-VEGFR2 Antibody (Bevacizumab), FITC Labled], a Anti-FITC CAR System (CAR-NR-ZP1316)

Fluorescein isothiocyanate (FITC) is a synthetic dye that is physiologically deficient in human body and has been used widely as a flowcytometry marker to label antibodies. The anti-FITC CAR contains two essential elements, one is a FITC-tagged tumor-targeting switch molecule and the other is a transmembrane CAR with an anti-FITC scFv. The FITC-labeled switch molecules form a pseudo-immunological synapse between anti-FITC CAR T cells and tumor cells expressing a given antigen, such as folate receptor or CD19, leading to lysis of the corresponding tumor cells.

Creative Biolabs provides customized Anti-FITC CAR design and construction services. Please contact us for more detailed information.

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CAR Schemeitc

UniCAR

  • CAR Construction
  • Anti-FITC scFv-41BB-CD3ζ
  • Discription of Signaling Cassetes
  • 41BB
    CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigennonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric 4-1BB and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
  • Vector Name
  • pCDCAR1
  • Vector length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Targeting Diseases
  • Melanoma

CAR Adaptor

  • Adaptor Target
  • VEGFR2
  • Common Name
  • KDR
  • Adaptor Type
  • FITC Labeld Antibody
  • Antibody Host
  • Human
  • Antibody Clone
  • Bevacizumab
  • CAR Adaptor Tag
  • FITC

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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