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Anti-MOG (MEVGWYRSPFSRVVHLYRNGK) TCR, pLXSN (TCR-L073)

The vector of anti-MOG T cell receptor (TCR) is constructed for the engineering of T cell to target Mouse MOG. The T cells are genetically modified through transduction with a retroviral vector expressing MOG-specific T cell receptor. And the vector product was designed for the treatment of Multiple sclerosis (MS).

Details

  • Target
  • MOG
  • Target Species
  • Mouse
  • Epitope
  • MEVGWYRSPFSRVVHLYRNGK
  • Format
  • Non-modified TCR
  • HLA
  • I-Ab
  • Targeting Diseases
  • Multiple sclerosis (MS)
  • Vector Name
  • pLXSN
  • Vector Length
  • 6714-6688bp
  • Vector Type
  • retroviral vector
  • Antibody Host
  • Mouse

Target

  • Gene Name
  • myelin oligodendrocyte glycoprotein
  • Official Symbol
  • MOG
  • Synonyms
  • P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector
  • Introduction
  • The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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