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Anti-TRRAP T cell receptor (T7), pCDTCR1 (TCR-L220)


All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-TRRAP T cell receptor (TCR) is constructed for the engineering of T cell to target Human TRRAP. The T cells are genetically modified through transduction with a lentiviral vector expressing TRRAP-specific T cell receptor. And the vector product was designed for the treatment of Breast cancer.

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Details

  • Target
  • TRRAP
  • Target Species
  • Human
  • Epitope
  • KLVFGSVFL
  • Format
  • Non-modified
  • Allele
  • HLA-A201
  • Targeting Diseases
  • Breast cancer
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • TCR Clone
  • T7
  • Host Species
  • Human

Target

  • Official Symbol
  • TRRAP
  • Introduction
  • This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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