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ADAM17

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-WFY2603 Anti-ADAM17 (CBFYC-0556) h(41BB-CD3ζ) CAR, pCDCAR1 Human CBFYC-0556 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-WFY5856 Anti-ADAM17 (CBFYC-0556) h(CD28-CD3ζ) CAR, pCDCAR1 Human CBFYC-0556 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP249 ADAM17 (ITGA5 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human ADAM17-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP250 ADAM17 (ITGB1 Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human ADAM17-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1649 ADAM17 (ITGA5 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human ADAM17-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1222-ZP1650 ADAM17 (ITGB1 Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human ADAM17-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
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