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THPO

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]
  • CAR Vector Products

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    CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
    XS-1222-ZP1203 THPO (MPL Receptor) h(CD28-CD3ζ) Ligand-based CAR, pCDCAR1 Human THPO-CD28-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
    XS-1222-ZP2603 THPO (MPL Receptor) h(41BB-CD3ζ) Ligand-based CAR, pCDCAR1 Human THPO-41BB-CD6ζ Lentiviral vector T cell   Add to Cart   Datasheet
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