VivoCAR™ Anti-CD44v6 (BIWA 4) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX69)

Name: VivoCAR™ Anti-CD44v6 (BIWA 4) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX69
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CD44v6 (BIWA 4) h(CD28-41BB-CD3z) CAR circRNA leverages the humanized BIWA 4 clone to target the stem-cell-like variants of squamous cell carcinomas in vivo. The BIWA 4 clone is critically important for its ability to recognize the v6 exon-encoded epitope, which is a hallmark of metastatic potential and therapy resistance. By utilizing a non-integrating circRNA vector, this product enables a potent but transient surge of CAR-T activity, specifically aimed at purging cancer stem cells. This provides a safe, repeatable method for preventing tumor recurrence while avoiding the long-term toxicities associated with permanent CD44v6 targeting in healthy epithelial tissues.

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Target Information

Target
CD44v6

Common Name
CD44v6

Alternative Names
Phagocytic Glycoprotein-1 (Pgp-1) splice variant, CD44 Variant Exon 6

Full Name
Cluster of Differentiation 44 Variant 6

Introduction
CD44v6 is a splice variant of the ubiquitously expressed adhesion molecule CD44. Unlike the standard CD44 form, the v6 variant is highly and preferentially expressed on cancer stem cells (CSCs) and metastatic tumor cells in many solid tumors, driving cell migration, invasion, and resistance to therapy. Its restricted expression on normal tissue makes it an attractive and specific target for eliminating CSCs.

Targeting Diseases
Head and Neck Cancer, Colorectal Cancer, Pancreatic Cancer, Breast Cancer

UniProt ID
P16070

Gene ID
960

Target Species
Human

Antibody Clone
BIWA 4

scFv-Host Species
Human

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

VivoCAR™ Anti-CD44v6 (BIWA 4) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX69)

Target Information

Customer Reviews and Q&As

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