VivoCAR™ Anti-CD79A (01) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX78)

Name: VivoCAR™ Anti-CD79A (01) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX78
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CD79A (01) h(CD28-41BB-CD3z) CAR circRNA utilizes a specialized binder to target the signaling component of the B-cell receptor (BCR) complex. In the context of in vivo engineering, this product is essential for clearing B-cell malignancies that have undergone CD19 or CD20 antigen escape. The circRNA platform allows for a transient therapeutic surge of CAR expression, enabling precision-guided depletion of malignant B-lineages. This non-viral approach ensures a clean safety profile, preventing long-term humoral immunodeficiency by allowing the B-cell compartment to reconstitute after the circRNA treatment cycle.

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Target Information

Target
CD79A

Common Name
CD79A

Alternative Names
IGA, IGAlpha, MB-1, MB1

Full Name
Cluster of Differentiation 79a

Introduction
CD79a is one half of the disulfide-linked CD79a/CD79b heterodimer, which constitutes the signaling component of the B-Cell Receptor (BCR) complex. It is expressed exclusively on B cells at all stages of development, from pro-B cells to plasma cells (unlike CD19 or CD20). Its consistent and restricted expression makes it an excellent target for virtually all B-cell malignancies.

Targeting Diseases
B-cell Acute Lymphoblastic Leukemia (B-ALL), Non-Hodgkin Lymphoma (NHL), Chronic Lymphocytic Leukemia (CLL)

UniProt ID
P11912

Gene ID
973

Target Species
Human

Antibody Clone
anti-CD79A-01

scFv-Host Species
Mouse

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

VivoCAR™ Anti-CD79A (01) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX78)

Target Information

Customer Reviews and Q&As

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