VivoCAR™ Anti-CD79A (10_HL) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX79)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CD79A (anti-CD79A-10_HL) h(CD28-41BB-CD3z) CAR circRNA features a humanized high-stability ScFv designed for optimal folding and surface display. The importance of the anti-CD79A-10_HL clone lies in its ability to penetrate dense lymphoid tissues to reach malignant B-cell niches. By delivering this CAR via the circRNA-LNP system, we enable a potent, iterative dosing strategy. This provides a sophisticated tool for researchers seeking to purge refractory lymphomas through a controlled, transient expression window, eliminating the risk of insertional mutagenesis and permanent genomic modification.

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Target Information

  • Target
  • CD79A
  • Common Name
  • CD79A
  • Alternative Names
  • IGA, IGAlpha, MB-1, MB1
  • Full Name
  • Cluster of Differentiation 79a
  • Introduction
  • CD79a is one half of the disulfide-linked CD79a/CD79b heterodimer, which constitutes the signaling component of the B-Cell Receptor (BCR) complex. It is expressed exclusively on B cells at all stages of development, from pro-B cells to plasma cells (unlike CD19 or CD20). Its consistent and restricted expression makes it an excellent target for virtually all B-cell malignancies.
  • Targeting Diseases
  • B-cell Acute Lymphoblastic Leukemia (B-ALL), Non-Hodgkin Lymphoma (NHL), Chronic Lymphocytic Leukemia (CLL)
  • Target Species
  • Human
  • Antibody Clone
  • anti-CD79A-10_HL
  • scFv-Host Species
  • Mouse
  • Receptor_Construction
  • CD28-41BB-CD3z
  • Generation
  • Third
  • Description of Signaling Cassetes
  • The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.
  • Structure
  • Circula
  • Product Type
  • CAR IVT circRNA
  • Concentration
  • Lot specific
  • Storage
  • Aliquot and store at -80°C. Avoid freeze/thaw cycles.
  • Handling
  • Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.
  • IVT Vector Sequencing
  • Pass
  • IVT Vector Enzyme Digestion
  • Pass
  • Purity OD260/280
  • Pass
  • RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
  • Pass
  • RNA Sequence Assessment
  • Pass
  • Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
  • Pass
  • Endotoxin (<10 EU/mg)
  • Pass
  • In Vitro Transfection and Expression (Optional)
  • Pass

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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