VivoCAR™ Anti-GYPA (R18) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX118)

Name: VivoCAR™ Anti-GYPA (R18) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX118
Rating: 5 (1 reviews)

Online Inquiry Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-GYPA (R18) h(CD28-41BB-CD3z) CAR circRNA utilizes the R18 clone, optimized for its ability to recognize GYPA epitopes that are exposed during abnormal erythroid differentiation. For in-situ immune redirection, this clone ensures that transiently reprogrammed T cells maintain high specificity for the leukemic niche. The circular RNA architecture protects the transcript from degradation, providing a steady supply of CAR protein during the therapeutic window. This offers a repeatable, safe method for managing refractory erythroleukemias without the risks of permanent genetic modification or chronic hemolytic toxicity.

Add to Cart

Target Information

Target
GYPA

Common Name
GYPA

Alternative Names
CD235a, GPA, GPErik, GPSAT, HGpMiV, HGpMiXI, HGpSta(C), MN, MNS, PAS-2

Full Name
Glycophorin A

Introduction
GYPA is the major sialoglycoprotein of the human erythrocyte membrane. While primarily known as a marker for mature red blood cells and their precursors, it is aberrantly expressed in Erythroleukemia (AML-M6) and certain other hematological malignancies. Because of its massive presence on healthy RBCs, CAR-T cell targeting of GYPA is highly specialized, often used in transient platforms or as a part of gated logic circuits to treat specific erythroid-lineage leukemias while minimizing systemic hemolysis.

Targeting Diseases
Erythroleukemia (AML-M6), Chronic Myelogenous Leukemia (CML) in blast crisis

UniProt ID
P02724

Gene ID
2993

CAR Information

Target Species
Human

Antibody Clone
R18

scFv-Host Species
Mouse

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

CAR circRNA Properties

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

circRNA Properties and Quality Control

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Case Studies

Customer Reviews and Q&As

There are currently no customer reviews or questions for VivoCAR™ Anti-GYPA (R18) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX118). Click the button below to contact us or submit your feedback about this product.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.