VivoCAR™ Anti-KLK2 (KL2B359) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX125)

Name: VivoCAR™ Anti-KLK2 (KL2B359) h(CD28-41BB-CD3z) CAR circRNA
SKU: XS-1225-YX125
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-KLK2 (KL2B359) h(CD28-41BB-CD3z) CAR circRNA employs the KL2B359 clone to target the prostate-specific protease KLK2. This clone is significant for its ability to distinguish between active and zymogen forms of the enzyme on the surface of prostate cancer cells. By delivering this CAR via the circRNA platform, the product achieves a transient, high-potency response that debulks metastatic prostate lesions. The non-integrating nature of the transcript provides a self-limiting therapeutic window, offering a safe alternative to traditional gene therapy for targeting tissue-specific androgen-regulated markers.

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Target Information

Target
KLK2

Common Name
KLK2

Alternative Names
KLK2A2, hGK-1, hK2

Full Name
Kallikrein-Related Peptidase 2

Introduction
KLK2 is a serine protease that shares significant sequence homology with PSA (KLK3). It is highly and specifically expressed in prostatic tissue and is dramatically upregulated in Prostate Cancer, particularly in poorly differentiated and metastatic lesions. Unlike PSA, which is largely secreted, KLK2 has a higher proportion of membrane-associated forms on malignant cells, making it an excellent target for CAR T-cell therapy, especially in cases where PSA-based screening might be less informative.

Targeting Diseases
Prostate Cancer, Metastatic Castration-Resistant Prostate Cancer (mCRPC)

UniProt ID
P20151

Gene ID
3817

Target Species
Human

Antibody Clone
KL2B359

scFv-Host Species
Human

Receptor_Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.

Structure
Circula

Product Type
CAR IVT circRNA

Concentration
Lot specific

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

VivoCAR™ Anti-KLK2 (KL2B359) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX125)

Target Information

Customer Reviews and Q&As

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