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Anti-NP 380 T cell receptor (YC39), pCDTCR1 (TCR-YC0746)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-NP 380 T cell receptor (TCR) is constructed for the engineering of T cell to target nucleoprotein (ELRSRYWAI) restricted by HLA-B8. The T cells are genetically modified through transduction with a lentiviral vector expressing NP 380-specific T cell receptor.

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Details

  • Target
  • NP 380
  • Target Species
  • IAV
  • Epitope
  • ELRSRYWAI
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-B8
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • YC39
  • Host Species
  • Human

Target

  • Introduction
  • Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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