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The Hy.1B11 TCR originated from a patient with relapsing– remitting MS and was specific for a peptide from MBP (res. 85–99) bound to HLA-DQ1 (DQ1; DQA1*0102, DQB1*0502). It was showed that the human Hy.1B11 T cell clone was not only activated by MBP but also by four peptides from human pathogens that were quite distinct from MBP and each other. Previous studies also provided evidence for in vivo expansion of T cells expressing the Hy.1B11 TCR: the same α and β chain sequences were isolated from three independent clones (originating from two different blood samples drawn 13 months apart). Such in vivo expansion may have been caused by recognition of a crossreactive antigen or MBP. The structure of Hy.1B11 TCR bound to DQ1/MBP peptide revealed a binding mode in which the TCR was strongly tilted relative to the DQ1/peptide surface.
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