pCDCAR1 CD33 h(DAP10)(CAR-MZ004)

The vector of anti-CD33 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human CD33. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-CD33 antibody linked to DAP10 signaling domains. And the vector product was designed for the treatment of CD33 positive cancers.


Details


Target
CD33
Target Species
Human
Targeting Cell Type
T cell
Targeting Diseases
CD33 positive cancers
Generation
First
Vector Name
pCDCAR1
Vector Length
~8kb
Vector Type
Retroviral
Receptor Construction
scFv-DAP10
Discription of Signaling Cassetes
DAP10
DNAX-activating protein 10 (DAP10) is a transmembrane adaptor protein for natural killer group 2, member D (NKG2D), directly binds to RAGE and modulates the S100A8/A9-triggered signaling pathway. DAP10 as well as S100A8/A9 and RAGE were overexpressed in psoriatic epidermis.
Antibody Host
Human

Target


Gene Name
CD33 molecule
Official Symbol
CD33
Gene ID
Synonyms
CD33; CD33 molecule; p67; SIGLEC3; SIGLEC-3; AML; acute myeloid leukaemia; leukaemia; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; CAMPATH-1H

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products


LeukemiaCarcinoma

Online Inquiry

Name:
Phone:
*E-mail Address:
*Service & Products Interested:
Project Description:
*Verification Code:
Please input "biolabs"(case insensitive) as verification code.
CB Promise
CONTACT US
45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-871-5806
Europe: 44-207-048-3343
Fax: 1-631-207-8356
Email:
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-048-3343

Distributors

To view the contact information for a specific location, select the desired country:

Australia
australia

FOLLOW US ON