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pCDCAR1 CD33 h(DAP10) (CAR-MZ004)

The vector of anti-CD33 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human CD33. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-CD33 antibody linked to DAP10 signaling domains. And the vector product was designed for the treatment of CD33 positive cancers.

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Details

  • Target
  • CD33
  • Target Species
  • Human
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • CD33 positive cancers
  • Generation
  • First
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Retroviral
  • Receptor Construction
  • scFv-DAP10
  • Discription of Signaling Cassetes
  • DAP10
    DNAX-activating protein 10 (DAP10) is a transmembrane adaptor protein for natural killer group 2, member D (NKG2D), directly binds to RAGE and modulates the S100A8/A9-triggered signaling pathway. DAP10 as well as S100A8/A9 and RAGE were overexpressed in psoriatic epidermis.
  • Antibody Host
  • Human

Target

  • Gene Name
  • CD33 Molecule
  • Official Symbol
  • CD33
  • Synonyms
  • CD33 Molecule; Sialic Acid-Binding Ig-Like Lectin 3; CD33 Antigen (Gp67); SIGLEC-3; SIGLEC3; Gp67;

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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