Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
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EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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EXPLORE MOREAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
The vector of anti-EGFRvIII chimeric antigen receptor (CAR) is constructed for the engineering of NK cells to target human EGFRvIII. The NK cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-EGFRvIII antibody linked to DAP12 signaling domains. And the vector product was designed for the treatment of Glioblastoma.
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Fig.1 Affinity determination of RAbDMvIII by Saturation ELISA. The concentration range for RAbDMvIII and RAbvIII was 20 to 0.02 ug/ml (x axis) and the absorbance was read at 450 nm (Y axis). Gupta, Puja, et al. "Development of an EGFRvIII specific recombinant antibody." BMC biotechnology 10 (2010): 1-13. Distributed under Open Access license CC BY 2.0. |
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Fig.2 Specificity of RAbDMvII1 by Flow cytometry. Flow cytometric analysis of surface expressed EGFRvIII. Gupta, Puja, et al. "Development of an EGFRvIII specific recombinant antibody." BMC biotechnology 10 (2010): 1-13. Distributed under Open Access license CC BY 2.0. |
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