The vector of anti-EGFRvIII chimeric antigen receptor (CAR) is constructed for the engineering of NK cells to target human EGFRvIII. The NK cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-EGFRvIII antibody linked to DAP12 signaling domains. And the vector product was designed for the treatment of Glioblastoma.


  • Target
  • Target Species
  • Human
  • Targeting Cell Type
  • NK cell
  • Targeting Diseases
  • Glioblastoma
  • Generation
  • First
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • Receptor Construction
  • scFv-DAP12
  • Discription of Signaling Cassetes
  • DAP12
    DAP12 is a 12 kDa transmembrane protein recently recognized as a key signal transduction receptor element in Natural Killer (NK) cells. It is a disulfide-linked homodimer that non-covalently associates with several activating receptors expressed on NK cells.
  • Antibody Clone
  • MR1.1
  • Antibody Host
  • Human


  • Gene Name
  • Epidermal Growth Factor Receptor
  • Official Symbol
  • EGFR
  • Synonyms
  • C-erb; c-erbB; CG10079; D-Egf; d-egf-r; D-EGFR; degfr; dEgfr; dEGFr; dEGFR; Degfr; DEgfr; DEGFR; dEGFR1; der; Der; DER; DER flb; DER/EGFR; DER/top; DER/torpedo; DER1; Dmel\CG10079; DmHD-33; EC2-4; EFG-R; Egf; Egf-r; EGF-R; egfr; EgfR; EGfr; EGFr; EGFR; EK2-6; El; Elp; Elp-1; Elp-B1; Elp-B1RB1; flb; Flb; HD-33; l(2)05351; l(2)09261; l(2)57DEFa; l(2)57Ea; l(2)57EFa; mor1; top; Top; TOP; top/DER; top/flb; Tor; Torpedo/DER; torpedo/egfr; torpedo/Egfr; Torpedo/Egfr

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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