VivoCAR™ Anti-CCR2 (1D9RKB) h(CD28-41BB-CD3z) CAR saRNA (XS-0326-XU91)

Name: VivoCAR™ Anti-CCR2 (1D9RKB) h(CD28-41BB-CD3z) CAR saRNA
SKU: XS-0326-XU91
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CCR2 (1D9RKB) h(CD28-41BB-CD3z) CAR saRNA utilizes the saRNA platform to express the 1D9RKB clone. In vivo, this clone is critical for targeting CCR2-positive myeloid-derived suppressor cells (MDSCs) that shield tumors from immune attack. The biological magnification effect of saRNA ensures that a minimal systemic dose leads to robust CAR expression, enabling T cells to reprogram in situ and remodel the tumor microenvironment by eliminating immunosuppressive populations, thereby enhancing the efficacy of combined immunotherapies.

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CAR Information

Target
CCR2

Target Species
Human

Antibody Clone
1D9RKB

scFv Host Species
Human

Receptor Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation CD28-41BB-CD3ζ architecture employs a sequential costimulatory strategy, where the CD28 module drives rapid initial activation and metabolic reprogramming, while the 4-1BB component sustains long-term cellular viability and mitigates exhaustion. This tandem design, anchored by the CD3ζ signaling chain, synergistically amplifies downstream signal transduction, resulting in a balanced T-cell phenotype with robust effector capacity and prolonged durability. The integrated signaling cascade thus optimizes both kinetic expansion and persistence, enhancing antitumor efficacy.

CAR saRNA Properties

Structure
Linear

Cap
Cap 1

PolyA
Segmented PolyA

Product Type
CAR IVT saRNA

Concentration
Lot specific

Buffer
1 mM Sodium Citrate, pH 6.4 (or specialized RNA storage buffer, RNase-free).

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

saRNA Quality Control

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Target Information

Full Name
C-C Chemokine Receptor Type 2

Alternative Names
CC-CKR-2; CCR-2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD; CCR2

Introduction
CCR2 is a chemokine receptor expressed on monocytes and MDSCs, driving their recruitment to inflammatory and tumor sites. It is a key mediator of tumor-induced immunosuppression and is also expressed on some leukemic cells.

Targeting Diseases
Pancreatic Ductal Adenocarcinoma (PDAC), Breast Cancer, Colorectal Cancer, Certain Leukemias

UniProt ID
P41597

Gene ID
729230

Case Studies

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.