VivoCAR™ Anti-CD34 (2E10) h(CD28-41BB-CD3z) CAR saRNA (XS-0326-XU62)

Name: VivoCAR™ Anti-CD34 (2E10) h(CD28-41BB-CD3z) CAR saRNA
SKU: XS-0326-XU62
Rating: 5 (1 reviews)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CD34 (2E10) h(CD28-41BB-CD3z) CAR saRNA leverages high-efficiency saRNA to deliver the 2E10 clone. For in situ T-cell reprogramming, the 2E10 clone is prized for its unique epitope recognition on CD34+ blasts. The saRNA platform achieves a "biological magnification" effect-where intracellular replication leads to sustained CAR expression-enabling the host's immune cells to identify and eliminate malignant progenitor cells in the bone marrow while maintaining a dose-sparing safety profile for systemic administration.

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CAR Information

Target
CD34

Target Species
Human

Antibody Clone
2E10

scFv Host Species
Mouse

Receptor Construction
CD28-41BB-CD3z

Generation
Third

Description of Signaling Cassetes
The third-generation CD28-41BB-CD3ζ architecture employs a sequential costimulatory strategy, where the CD28 module drives rapid initial activation and metabolic reprogramming, while the 4-1BB component sustains long-term cellular viability and mitigates exhaustion. This tandem design, anchored by the CD3ζ signaling chain, synergistically amplifies downstream signal transduction, resulting in a balanced T-cell phenotype with robust effector capacity and prolonged durability. The integrated signaling cascade thus optimizes both kinetic expansion and persistence, enhancing antitumor efficacy.

CAR saRNA Properties

Structure
Linear

Cap
Cap 1

PolyA
Segmented PolyA

Product Type
CAR IVT saRNA

Concentration
Lot specific

Buffer
1 mM Sodium Citrate, pH 6.4 (or specialized RNA storage buffer, RNase-free).

Storage
Aliquot and store at -80°C. Avoid freeze/thaw cycles.

Handling
Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.

saRNA Quality Control

IVT Vector Sequencing
Pass

IVT Vector Enzyme Digestion
Pass

Purity OD260/280
Pass

RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
Pass

RNA Sequence Assessment
Pass

Endotoxin (<10 EU/mg)
Pass

In Vitro Transfection and Expression (Optional)
Pass

Target Information

Full Name
Cluster of Differentiation 34

Alternative Names
Hematopoietic Stem Cell Antigen 34

Introduction
CD34 is a glycosylated transmembrane protein and a well-known marker for hematopoietic stem cells and vascular endothelial cells. It plays a role in cell-cell adhesion and signal transduction during hematopoiesis.

Targeting Diseases
Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Angiosarcoma

UniProt ID
P28906

Gene ID
947

Case Studies

Customer Reviews and Q&As

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.