VivoCAR™ Anti-CD56 (m905) h(CD28-41BB-CD3z) CAR circRNA (XS-1225-YX55)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

VivoCAR™ Anti-CD56 (m905) h(CD28-41BB-CD3z) CAR circRNA leverages the humanized m905 clone, which features optimized binding kinetics for aggressive multiple myeloma cells. The significance of the m905 clone in an in vivo setting lies in its ability to trigger potent cytolytic signaling upon minimal antigen contact. The circular RNA platform provides an extended protein translation half-life, ensuring that transiently redirected T cells can maintain their anti-myeloma activity within the bone marrow niche, providing a sophisticated, repeatable therapeutic strategy that avoids the long-term toxicities of permanent CAR-T manufacturing.

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Target Information

  • Target
  • CD56
  • Common Name
  • CD56/NCAM1
  • Alternative Names
  • NCAM1, NCAM, MSK39
  • Full Name
  • Neural Cell Adhesion Molecule 1
  • Introduction
  • CD56 is a homophilic adhesion molecule normally expressed on Natural Killer (NK) cells and certain T cells. Critically, it is highly expressed on several hematological malignancies and neuroendocrine tumors, including Multiple Myeloma, NK/T cell lymphoma, and Small Cell Lung Cancer, making it an established immunotherapy target.
  • Targeting Diseases
  • Multiple Myeloma (MM), Acute Myeloid Leukemia (AML), NK/T cell lymphoma, Small Cell Lung Cancer (SCLC)
  • Target Species
  • Human
  • Antibody Clone
  • m905
  • scFv-Host Species
  • Human
  • Receptor_Construction
  • CD28-41BB-CD3z
  • Generation
  • Third
  • Description of Signaling Cassetes
  • The third-generation signaling cassette integrates two costimulatory domains, CD28 for initial robust expansion and 4-1BB for enhanced persistence, coupled with the primary CD3zeta domain for potent cytotoxic T-cell function.
  • Structure
  • Circula
  • Product Type
  • CAR IVT circRNA
  • Concentration
  • Lot specific
  • Storage
  • Aliquot and store at -80°C. Avoid freeze/thaw cycles.
  • Handling
  • Thaw and work with RNA on ice. Upon first use, pulse spin before opening and aliquot into single use portions. DO NOT vortex. Use only certified RNase-free reagents and consumables with proper RNase-free technique. Use of barrier tips is recommended. Avoid freeze/thaw cycles. DO NOT mix with media containing serum unless first complexed with a stabilizing transfection reagent.
  • IVT Vector Sequencing
  • Pass
  • IVT Vector Enzyme Digestion
  • Pass
  • Purity OD260/280
  • Pass
  • RNA Length and Integrity Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
  • Pass
  • RNA Sequence Assessment
  • Pass
  • Cyclization Efficiency Assessment (Determined by Denaturing Agarose Gel Electrophoresis)
  • Pass
  • Endotoxin (<10 EU/mg)
  • Pass
  • In Vitro Transfection and Expression (Optional)
  • Pass

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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